Basic Information
VIS ID
TVIS30000069
Fusion event
HIV-THADA integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
43604580/43377441 (Hg38)
End
43604580/43377441 (Hg38)
Orient
-
Location type
Intronic
Target gene
THADA
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-106b-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1301/Upstream/7905955; hsa-mir-10b/Downstream/4000234;
Nearest TSS
ENST00000437798/Upstream/5204; ENST00000460356/Downstream/14481;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/149629, chr2-CpG: 42/Downstream/218348
Upstream sequence
TGACTGAGGTGACATATGATGTTTCCCCCTCCTCTTTAGACATAGATTTTTTTTTTAAGGAAAAAATGTGTTAAATATACCAAGCTCAATGGCAAGAAAG
Downstream sequence
GGAATCTCCAAATGCCAGATATAAAGAAGGAACTTAGAGCCAGGGTGATAGATGAGGTGCAGTGACCCACAGGGGAATTAGATGCTGAGCTGAGAGCACT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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