Basic Information
VIS ID
TVIS30000071
Fusion event
HIV-EXOC2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
647555/647555 (Hg38)
End
647555/647555 (Hg38)
Orient
+
Location type
Intronic
Target gene
EXOC2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-570-3p ; hsa-mir-5582-3p ; hsa-mir-548as-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-659-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-203a-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-1252-3p
Nearest miRNA
hsa-mir-10398/Downstream/742759;
Nearest TSS
ENST00000381078/Upstream/123384; ENST00000607644/Downstream/9408;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/110033, chr6-CpG: 76/Downstream/8854
Upstream sequence
cactgtaacctagagatgctgagtgtctttttcaagagcacacacctgatgagttgtcaaacagaccagattcctggtgaccggatctgtaagagtctag
Downstream sequence
tatcctcttccttctgtaccacCATATGTCCTGTGAGGTCATTTGTGAATGTGACCGCTCACATTCTAATAACCTTCATTGTGTCTCCAGTGACTGGGGC
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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