Basic Information
VIS ID
TVIS30000074
Fusion event
HIV-SUN1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
884106/844469 (Hg38)
End
884106/844469 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
SUN1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p
Nearest miRNA
hsa-mir-10399/Downstream/178464;
Nearest TSS
ENST00000635602/Upstream/1099; ENST00000463848/Downstream/4139;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/21306, chr7-CpG: 61/Downstream/2697
Upstream sequence
aggagggcagggccaggtctgtcttatccacTCCGAGCCTGGCATTGCCCGGGACGTGGGGCGTTTGTCCAGTATTATTCAAATGACCGGACATAATGAA
Downstream sequence
GGATGGCGACAGGACGAAGGCTTCTGCCCTAAGATTTCTCGCATCTCGTTTTTACCATCTTGTCTTCGTGGCCCTCACTTGTGGTTGTGTCTGCTGTGGT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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