Basic Information
VIS ID
TVIS30000076
Fusion event
HIV-ILRUN integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
34648569/34680792 (Hg38)
End
34648569/34680792 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ILRUN
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-10b-5p ; hsa-mir-6510-5p ; hsa-mir-5739 ; hsa-mir-3175 ; hsa-mir-6734-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-3123 ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-766-5p ; hsa-mir-3605-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3928-3p ; hsa-mir-4330 ; hsa-mir-4709-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-483-3p ; hsa-mir-1228-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5581-3p ; hsa-mir-8064 ; hsa-mir-6872-3p ; hsa-mir-7151-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1236/Upstream/440056; hsa-mir-10398/Downstream/789716;
Nearest TSS
ENST00000381078/Upstream/8836; ENST00000606971/Downstream/15525;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/136303, chr6-CpG: 55/Downstream/15503
Upstream sequence
tctgcctgcctcggcctcccaaaggtgtgagccatcacgactggcctattttttatttttatatttttttctattttttttaaCTTTTTGCCAACATTCG
Downstream sequence
GATCCTAACAATTTTTTTTTCttcagagcaggagtgaaagtttattttaaaaggctttagaacaggaaagaaagaaaaagtacacctggaagagacccaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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