Basic Information
VIS ID
TVIS30000084
Fusion event
HIV-FCHSD2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
72684123/72973078 (Hg38)
End
72684123/72973078 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
FCHSD2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7159-3p ; hsa-mir-4668-5p ; hsa-mir-210-3p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-4272 ; hsa-mir-3613-3p ; hsa-mir-6074 ; hsa-mir-3622a-5p ; hsa-mir-548an ; hsa-mir-4482-3p ; hsa-mir-4474-5p ; hsa-mir-4662a-5p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-449b-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-10392/Upstream/189486; hsa-let-7a-2/Downstream/1426159;
Nearest TSS
ENST00000527297/Upstream/85503; ENST00000541254/Downstream/15934;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/150349, chr11-CpG: 192/Downstream/168053
Upstream sequence
tagcacaagtgagccagggagaatgtacaagactgttgataacagcactgtttgtaacagtaaaacaataaacaactaaaatttccattaagaaaatggg
Downstream sequence
taagttatggccgggcgcggtggctcatgcctataatcccagcaccttggaggccaaggcaggcggatcacctgaggtcaggagttcaagaccagcctga
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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