Basic Information
VIS ID
TVIS30000087
Fusion event
HIV-DHX15 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
24538095/24536472 (Hg38)
End
24538095/24536472 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
DHX15
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-484 ; hsa-mir-378a-3p ; hsa-mir-221-3p ; hsa-mir-26a-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12113/Upstream/16182; hsa-mir-1243/Downstream/4283110;
Nearest TSS
ENST00000502981/Upstream/2273; ENST00000569621/Downstream/2678;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/63166, chr4-CpG: 63/Downstream/47340
Upstream sequence
ttctgggtcaaagagtatacagttgctaaagttcctggtaacataAAATCAACTTTTCATAAAGACCACAACTAACCCCACTCCCATACAGCTAAGGAAT
Downstream sequence
ATTTTTCAATATCTGCAAATTTTATGTGAGAAAATGGTAATGCCTTTCATTATCAATAATAATGCCAAAATAATAATGCACTTCTTGGGCTAACAGTAGA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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