Basic Information
VIS ID
TVIS30000091
Fusion event
HIV-IFT140 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1646038/1596037 (Hg38)
End
1646038/1596037 (Hg38)
Orient
-
Location type
Intronic
Target gene
IFT140
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-6874-5p ; hsa-mir-6500-5p ; hsa-mir-4633-3p ; hsa-mir-6080 ; hsa-mir-558 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-3176/Upstream/825760; hsa-mir-11401/Downstream/138948;
Nearest TSS
ENST00000527434/Upstream/11774; ENST00000498594/Downstream/14007;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/40693, chr16-CpG: 424/Downstream/14016
Upstream sequence
cccagctacttgggaggctgaggcacaagaattgcttgaacccaggaggcagagcttgcaatgagccaagatcccgccactgcactccagcctgggtgac
Downstream sequence
agagtgaggctccgtctaaaacaaacaaaaacaaacaaacaaacaaaACCACTATTGGTGTATTTGTGTTTAGtaatttttaaaaaatattttaaaaata
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate