Basic Information
VIS ID
TVIS30000093
Fusion event
HIV-RPTOR integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
78768011/80794211 (Hg38)
End
78768011/80794211 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPTOR
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10226/Upstream/374718; hsa-mir-1250/Downstream/331065;
Nearest TSS
ENST00000595228/Upstream/50924; ENST00000576366/Downstream/11421;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/47784, chr17-CpG: 24/Downstream/7580
Upstream sequence
aaatgtttactctctgaaagacacgctgatatgaaaagacaagctatagactcggagaaaatatttgcaagtcacatatctgacaaagaacacatgtatc
Downstream sequence
cagaatgtataaagatatctcaaaactcaaaaataagggggaaaagaaaattagaaaatagaccaaagacatgaagagacacttcaccaaagaggattta
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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