Basic Information
VIS ID
TVIS30000094
Fusion event
HIV-CREBBP integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3822414/3772413 (Hg38)
End
3822414/3772413 (Hg38)
Orient
+
Location type
Intronic
Target gene
CREBBP
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-1301-3p ; hsa-mir-935 ; hsa-mir-769-5p ; hsa-mir-125b-5p ; hsa-mir-100-5p ; hsa-let-7e-5p ; hsa-mir-543 ; hsa-mir-4635 ; hsa-mir-218-5p ; hsa-mir-33a-3p ; hsa-mir-1264 ; hsa-mir-6507-3p ; hsa-mir-4684-5p ; hsa-mir-3143 ; hsa-mir-601 ; hsa-mir-4765 ; hsa-mir-942-5p ; hsa-mir-1251-5p ; hsa-mir-517-5p ; hsa-mir-325 ; hsa-mir-628-3p ; hsa-mir-6729-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5586-3p ; hsa-mir-802 ; hsa-mir-2681-5p ; hsa-mir-302c-5p ; hsa-mir-5681b ; hsa-mir-571 ; hsa-mir-5680 ; hsa-mir-6512-5p ; hsa-mir-338-5p ; hsa-mir-4517 ; hsa-mir-1252-3p ; hsa-mir-219a-1-3p ; hsa-mir-4268 ; hsa-mir-4641 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4328
Nearest miRNA
hsa-mir-1225/Upstream/286944; hsa-mir-11401/Downstream/898905;
Nearest TSS
ENST00000527434/Upstream/1710; ENST00000571169/Downstream/2333;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/40996, chr16-CpG: 208/Downstream/107069
Nearest cancer related gene
CREBBP(TSG, No orient, 0)
Upstream sequence
CTCTCTGAAacacaaacacacacacacacacacacacacacacacacacacacGTTAGTTACTGAAAGAGAACTGTTTCAGTGcagtggttctatactgg
Downstream sequence
ggatacacttcagaattatttgtgaacattttaaaaatGATTCTGAATCACTGTTCTAGAGcaggggttggcaatctcccagggcaaacacactgagctg
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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