Basic Information
VIS ID
TVIS30000096
Fusion event
HIV-RABEP1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5223033/5319738 (Hg38)
End
5223033/5319738 (Hg38)
Orient
-
Location type
Intronic
Target gene
RABEP1
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-let-7f-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-552-3p ; hsa-mir-551b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1253/Upstream/349588; hsa-mir-10226/Downstream/1335702;
Nearest TSS
ENST00000595228/Upstream/37251; ENST00000570487/Downstream/12317;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/36891, chr17-CpG: 95/Downstream/99449
Upstream sequence
aggcgtgagctaccacacccagcctaccagagaaatttaacaaggatattgaaataattaaaaaattaaacagaagtcttagaactgataaatagatttt
Downstream sequence
ctcaactggaaaattcatcagaggctctcagtagcaaaatggatcaagcagaggaaagaagcagtgaccttgaagacaggctgtttgaaaatacaaagag
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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