Basic Information
VIS ID
TVIS30000097
Fusion event
HIV-ATR integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
142252336/142533494 (Hg38)
End
142252336/142533494 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATR
miRNAs that regulate target gene
hsa-let-7f-5p ; hsa-mir-185-5p ; hsa-mir-218-5p ; hsa-mir-383-5p
Nearest miRNA
hsa-let-7g/Upstream/8095588; hsa-mir-1224/Downstream/9032382;
Nearest TSS
ENST00000440867/Upstream/33392; ENST00000483373/Downstream/25507;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/85310, chr3-CpG: 56/Downstream/44883
Nearest cancer related gene
ATR(TSG, No orient, 0)
Upstream sequence
gctagtggctactgctgaagagtatagatatagaatattttcatcctcacagaaaggtcctttggacagtactATTGGAAGTCTTAATTCAATTGTATTC
Downstream sequence
AACTTTAATGCTATCTTCTTGCCACAGTTGGGAAAAAACCCATTTCCTTCTCTCTTTATTCCTAGGTGTTTTGGGCCAGTGCCTGCTGGAGTATGGTTAG
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate