Basic Information
VIS ID
TVIS30000104
Fusion event
HIV-MYDGF integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4659379/4659367 (Hg38)
End
4659379/4659367 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
MYDGF
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-1262 ; hsa-mir-1273g-3p ; hsa-mir-3134 ; hsa-mir-451b ; hsa-mir-4534 ; hsa-mir-4701-3p ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-6081 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6736-5p ; hsa-mir-6776-5p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-8082
Nearest miRNA
hsa-mir-1227/Upstream/213319; hsa-let-7e/Downstream/111303;
Nearest TSS
ENST00000633603/Upstream/3843; ENST00000381796/Downstream/5539;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6879, chr19-CpG: 85/Downstream/10548
Upstream sequence
ttgctgtcttccaggctagagtgcagtggcatgatctcagctcactgcaacctccacctcccaggttccagcaattctcctgaatagctgggattacagg
Downstream sequence
tgcgcaccaccacgcctggctaattttttgcatttttagtagagatggggtttcattatgttggccagctggtctggaactcctgacctcaagtgttccg
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate