Basic Information
VIS ID
TVIS30000108
Fusion event
HIV-NF1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
29563438/31236420 (Hg38)
End
29563438/31236420 (Hg38)
Orient
+
Location type
Intronic
Target gene
NF1
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-370-3p ; hsa-mir-20a-3p ; hsa-mir-193b-3p ; hsa-let-7e-5p ; hsa-mir-9-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-193a-3p ; hsa-mir-374a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-107 ; hsa-mir-514a-5p
Nearest miRNA
hsa-mir-1180/Upstream/141995; hsa-mir-10226/Downstream/298463;
Nearest TSS
ENST00000595228/Upstream/3390; ENST00000581113/Downstream/37202;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/140960, chr17-CpG: 29/Downstream/108897
Nearest cancer related gene
NF1(TSG, No orient, 0)
Upstream sequence
TTCATATGCAGTCACTTGCATGCATACTCTTTTTCTAACTCACTTCTTCTATGATGAGGAGTGACTTAGGAGAAGGGAAAGAGGCTAATAGGTAATGCAG
Downstream sequence
GCTGCAGTTTATTTATTTGTCATTTTTTTAAAAAtttgagacagagtctcactctgccattcaggctggggtgcactggcgcagtctcggctcactgcaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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