Basic Information
VIS ID
TVIS30000111
Fusion event
HIV-ZNF430 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
21218896/21036090 (Hg38)
End
21218896/21036090 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF430
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-8057 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-29b-1-5p ; hsa-mir-4772-3p ; hsa-mir-1304-3p ; hsa-mir-1237-3p ; hsa-mir-6890-3p ; hsa-mir-640 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p
Nearest miRNA
hsa-mir-10395/Upstream/636736; hsa-let-7e/Downstream/14086610;
Nearest TSS
ENST00000633603/Upstream/15373; ENST00000597922/Downstream/21715;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/983792, chr19-CpG: 19/Downstream/46268
Upstream sequence
ATGGTATATCAGTGTTGCACAGCAGATTTTATGAGTAAATATGTCACTTACTATTACTGCGCAGTTTCATATCAGTGTTTTGTTAGTGTAGGTTTCTTAA
Downstream sequence
CATTGAGTTATTGTGTTTTTTTGTTTCACTTTTGTATTATAATTTTAGACAGTTTGCAATTCGGTTTATCTCTTATAATTAAGAGATAAATCAGCCATAT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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