Basic Information
VIS ID
TVIS30000112
Fusion event
HIV-CEACAM21 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42063118/41556748 (Hg38)
End
42063118/41556748 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CEACAM21
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10395/Upstream/1186841; hsa-let-7e/Downstream/312879;
Nearest TSS
ENST00000633603/Upstream/7228; ENST00000401445/Downstream/7934;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/34407, chr19-CpG: 28/Downstream/8249
Upstream sequence
gcaaacattaaaccaaaggcgctggggccctgactgggaattgaacccaggccatggtggcgaaggcataaacttgaagctaggccacaatataaggcac
Downstream sequence
ctttcattgtgaatcccacagaatattgaaagcaggcagtatgaacttcaaaagatttttttggcagggggtcagattttttatctttaattttatcaga
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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