Basic Information
VIS ID
TVIS30000114
Fusion event
HIV-ZMYM4 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
35850410/35384809 (Hg38)
End
35850410/35384809 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZMYM4
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6789-3p ; hsa-mir-4707-3p ; hsa-mir-4258 ; hsa-mir-4438 ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4698 ; hsa-mir-4705 ; hsa-mir-548au-3p ; hsa-mir-551b-5p ; hsa-mir-7150 ; hsa-mir-8063
Nearest miRNA
hsa-mir-12136/Upstream/715115; hsa-mir-101-1/Downstream/1776754;
Nearest TSS
ENST00000473358/Upstream/18732; ENST00000470175/Downstream/7871;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/115555, chr1-CpG: 95/Downstream/172270
Upstream sequence
TTATAGGATGATATAGTATAAAAGCATGAACTTGCTGTTATTTaatgtttttaaaactgtggttatgacctattaatagaccctgaaattaattactagg
Downstream sequence
ttataaccagcattattatttttttctttttcttttttttttttttttttgaggtggaatcttctcattctgtcgccaggctggagtgcagtggcacgat
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate