Basic Information
VIS ID
TVIS30000116
Fusion event
HIV-SMG7 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
183452481/183483346 (Hg38)
End
183452481/183483346 (Hg38)
Orient
-
Location type
Intronic
Target gene
SMG7
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-935 ; hsa-mir-106b-5p ; hsa-mir-185-5p ; hsa-mir-93-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-493-3p ; hsa-mir-6741-3p ; hsa-mir-6867-3p ; hsa-mir-6873-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-4326 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-1203 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-584-3p ; hsa-mir-577
Nearest miRNA
hsa-mir-101-1/Upstream/3044956; hsa-mir-1182/Downstream/9232982;
Nearest TSS
ENST00000473358/Upstream/10414; ENST00000493609/Downstream/18942;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10226, chr1-CpG: 99/Downstream/151802
Upstream sequence
CATATAATAGTATTTCAGTGCTGTGTTAGTTGGGATACAGTATAATGGATGTGTCTGTTTTACTAATACTGCCTCTTAGAAAGGTTACGAATTATTTACT
Downstream sequence
TTTGTATCAGGTGATCACCTAACCAGATTATCTTTGAGATACTGTACAGTAATGAGATAATTAGTAGTGAGGTAATCAAAGGAAAATGCAACTGGAAGAT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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