Basic Information
VIS ID
TVIS30000119
Fusion event
HIV-PACS1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
65949773/66182302 (Hg38)
End
65949773/66182302 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PACS1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-526b-5p ; hsa-mir-431-5p ; hsa-mir-4711-5p ; hsa-mir-935 ; hsa-mir-3662 ; hsa-mir-6513-5p ; hsa-mir-599 ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-3145-3p ; hsa-mir-610 ; hsa-mir-3614-5p ; hsa-mir-4461 ; hsa-mir-6079 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-9-5p ; hsa-mir-8485 ; hsa-mir-1200 ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4682 ; hsa-mir-3653-5p ; hsa-mir-1304-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-2861 ; hsa-mir-3134 ; hsa-mir-449b-3p ; hsa-mir-4534 ; hsa-mir-602 ; hsa-mir-6081 ; hsa-mir-6749-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-10392/Upstream/533049; hsa-let-7a-2/Downstream/752132;
Nearest TSS
ENST00000527297/Upstream/81539; ENST00000531298/Downstream/33896;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/111124, chr11-CpG: 120/Downstream/75137
Upstream sequence
TGGTCTGTGCAAGTAATTGGCATTCATAACCCAAAGATAAACATACCCTGAGTAACTGAAAATTTTCTTAGAATCTTATGTCCCTCTACTTCATAGAAAG
Downstream sequence
CCACATCTTATGGCTATGGAGTAAAATATCCCTAAGGATGTTCCTTAGTTCTGTTTATTGTTTAGGCTTAAGTTTTTTCTCATTCGCTGATATTCTCCCA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate