Basic Information
VIS ID
TVIS30000121
Fusion event
HIV-KANSL2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
49065536/48671753 (Hg38)
End
49065536/48671753 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
KANSL2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/17223; hsa-let-7i/Downstream/100222;
Nearest TSS
ENST00000382841/Upstream/2528; ENST00000548054/Downstream/7940;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/143407, chr12-CpG: 66/Downstream/9953
Upstream sequence
cgttagcgtgagtcactccatgaagtttgaatgacaaaaatcacctaacaaagtatgtatccccatcattaagtgacacatgactgTACTACCAAATTCA
Downstream sequence
CATGTTAAACCCACAACAGCTTGTTGGAACTGGCATAAAACTTGCCTAGAGCTTCATGTTCCACTTTGCGATTATGTAAGTATCGGCGCTTCTTCTCCTT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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