Basic Information
VIS ID
TVIS30000122
Fusion event
HIV-MGMT integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
131298234/129499970 (Hg38)
End
131298234/129499970 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MGMT
miRNAs that regulate target gene
hsa-mir-181d-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-648 ; hsa-mir-767-3p ; hsa-mir-370-3p ; hsa-mir-661 ; hsa-mir-409-3p ; hsa-mir-124-3p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-107/Upstream/3680148; hsa-mir-202/Downstream/343329;
Nearest TSS
ENST00000439456/Upstream/32708; ENST00000462672/Downstream/201208;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/32524, chr10-CpG: 25/Downstream/279216
Upstream sequence
GAAATACATCCTTATGTCAGTTTTCACCCGATGACTGAAAATTGTTGGATATATGCGTGAAATAATTAGGTCTTATTTTTGGAAGGGAGAGAATATAACC
Downstream sequence
GACTGAAAAATAATTTGGAGTTAATTGTCCTGAAAATTCACCTACTGTATATTAATAGGTTAGGTGTTTCCTAATTCTTTCTTTCTTAAGCATATCTTCC
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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