Basic Information
VIS ID
TVIS30000125
Fusion event
HIV-ZNF700 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12043437/11932622 (Hg38)
End
12043437/11932622 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF700
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-1181/Upstream/437000; hsa-let-7e/Downstream/770979;
Nearest TSS
ENST00000633603/Upstream/7502; ENST00000482090/Downstream/14132;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/7004, chr19-CpG: 34/Downstream/32592
Upstream sequence
TCAGTACTGTGAACGATAACTGCCTTACTTTTCTTTATACTTCCCCAACCTGGGTACCCATCCACATCAGTATATTTTATTTTTGCATGTTTTTTATGCA
Downstream sequence
AACCAATATGTGAttttttttttttttttttttgagacagagtcttgccctgtcgcccaggctggagtgcagtggcgtgatctcggctcactgcaagctc
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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