Basic Information
VIS ID
TVIS30000127
Fusion event
HIV-NPHP3-ACAD11 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
132409302/132690458 (Hg38)
End
132409302/132690458 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
NPHP3-ACAD11
Nearest miRNA
hsa-let-7g/Upstream/704527; hsa-mir-1224/Downstream/1677346;
Nearest TSS
ENST00000440867/Upstream/5635; ENST00000489343/Downstream/4412;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29659, chr3-CpG: 57/Downstream/31411
Upstream sequence
AAAAGCAGATCTAATAGAGATTTGTAAATTGTCTCAAGATTTCTCCTACACTATTTGTATTTCAGATACTTAGACTAATTTTTAAATTAAAAATACCATT
Downstream sequence
TTTTCTTTGTTAAACTGAACAACTTTAAATCTCTCTTTCTGGGGAAAGATGTTCTATAATGTTTCTTACCTTTTATAAAGGTTTTGAGACACAAAGAGAT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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