Basic Information
VIS ID
TVIS30000128
Fusion event
HIV-DCLRE1C integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
14950636/14908637 (Hg38)
End
14950636/14908637 (Hg38)
Orient
-
Location type
Exonic
Target gene
DCLRE1C
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4495 ; hsa-mir-548n
Nearest miRNA
hsa-mir-1265/Upstream/471976; hsa-mir-107/Downstream/2936470;
Nearest TSS
ENST00000439456/Upstream/27137; ENST00000496225/Downstream/2685;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/28948, chr10-CpG: 64/Downstream/45044
Upstream sequence
TCAGAAGAGCTCTGGGAATCTGCATTTGTGCTAAGATTTAGCAAACTTTTTTCCTCGGGTATATGTGTCTCACTGCTTAGAGTAGTTGGTTCTCCAGTAC
Downstream sequence
TAGGAACTATTGTCACATCTTTATCTCTGCTTTTCAAATCAGAGTAAGTATCCTTTGGGCAAATTACATTTTGTTCCATGAGAGAGGCAGGAATATTCTC
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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