Basic Information
VIS ID
TVIS30000132
Fusion event
HIV-UTP20 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
101727774/101333996 (Hg38)
End
101727774/101333996 (Hg38)
Orient
+
Location type
Intronic
Target gene
UTP20
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-1276 ; hsa-mir-6778-3p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-1281 ; hsa-mir-3613-3p ; hsa-mir-614 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-6818-3p
Nearest miRNA
hsa-let-7i/Upstream/1144047; hsa-mir-1178/Downstream/2596429;
Nearest TSS
ENST00000382841/Upstream/7141; ENST00000551346/Downstream/67490;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/53618, chr12-CpG: 84/Downstream/73273
Upstream sequence
caggtgatccgcctgccttggcctcccaaagtgctgggattacaggcgtgagccactgtgcccggccTGTAACATGACTTTTATAGCACCTCACATAGCG
Downstream sequence
TTGCCTCTGGCTTTGGACAAGTGTGAGGGAAAACACCCAGGTGTTTTTATTACATACTTCCTATTTTGATTTCTCTGGTTGTAACCCCTTGGTGATGGTA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate