Basic Information
VIS ID
TVIS30000137
Fusion event
HIV-XAF1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
6671412/6768093 (Hg38)
End
6671412/6768093 (Hg38)
Orient
-
Location type
Intronic
Target gene
XAF1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1253/Upstream/112584; hsa-mir-10226/Downstream/249522;
Nearest TSS
ENST00000595228/Upstream/6375; ENST00000321535/Downstream/8130;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/53941, chr17-CpG: 49/Downstream/7793
Nearest cancer related gene
XAF1(TSG, No orient, 0)
Upstream sequence
aaatgctgccagaattttgtttcattttgctttcatactacccctctttactgattattgttgttatttatgtaactcatgcctgtttagatatactcac
Downstream sequence
atgtttttgtttttgctttttttctttctttctttctttttttttttgagacaaaagtctcactctgttgcctgggcttgagtgcagtggcacgatcttg
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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