Basic Information
VIS ID
TVIS30000139
Fusion event
HIV-SMYD3 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
246450646/246287344 (Hg38)
End
246450646/246287344 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
SMYD3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2941089; hsa-mir-3124/Downstream/914623;
Nearest TSS
ENST00000473358/Upstream/93617; ENST00000366511/Downstream/18665;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/35077, chr1-CpG: 74/Downstream/219502
Upstream sequence
AAGTCCAGAGTTGTTTTAAACTTAGAAAATATTTTCTAATATATATAGTTTTCGGAATAATAATTAGGTCAATGAGCTAAAGATTTCCTTTTACAGTTTC
Downstream sequence
ATTACAAATTTAAAAAGCTTTTGTAGTAAAAACCCATGAATGTAATCACTATTTAATAGTTTATGTTTTCTAAAAATGTGTTTGGCATTCCATCTGTTAA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate