Basic Information
VIS ID
TVIS30000140
Fusion event
HIV-ZNF274 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
58703251/58191884 (Hg38)
End
58703251/58191884 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF274
miRNAs that regulate target gene
hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-1324 ; hsa-mir-4524b-3p ; hsa-mir-197-3p ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-6765-3p ; hsa-mir-1228-3p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-4716-5p ; hsa-mir-4764-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-483-3p
Nearest miRNA
hsa-let-7e/Upstream/2803642; hsa-mir-10394/Downstream/142804;
Nearest TSS
ENST00000633603/Upstream/4937; ENST00000595146/Downstream/16214;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8144, chr19-CpG: 65/Downstream/11969
Upstream sequence
GATGCTGTCCTTCCTCTTCTCCttcttccacctcacagatacttatggagggccttttctgtcccatgcaatatacttactaaaaacttcggtgataaac
Downstream sequence
caaagcacttacataatctctaccatcttagacttcatagtctaaacaatgatggccttttacaaacatgttacacagatacagtgataaatgtactgag
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate