Basic Information
VIS ID
TVIS30000143
Fusion event
HIV-MND1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154331772/153410620 (Hg38)
End
154331772/153410620 (Hg38)
Orient
-
Location type
Intronic
Target gene
MND1
miRNAs that regulate target gene
hsa-mir-193b-3p
Nearest miRNA
hsa-mir-12113/Upstream/874104; hsa-mir-1305/Downstream/5718182;
Nearest TSS
ENST00000502981/Upstream/60556; ENST00000445960/Downstream/55726;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/65378, chr4-CpG: 131/Downstream/55062
Upstream sequence
AATTATTTTTTTCCTAGTCTATTTTAGAATTAGGTAGATTGGTAAAATCAATATAATTGGCCTTTAGTTTGTTTTTTAATGAAATTGCAGTCTTACTTAT
Downstream sequence
CATATAGCTTTTAAAGTTTGTTTTAATATTCATATTAAAATTATCATATAGAAAGAAAGTTTGCTTTATTTTTACTTAAAAAAGTCCTggccgggcgtgg
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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