Basic Information
VIS ID
TVIS30000147
Fusion event
HIV-KIF22 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29807282/29795961 (Hg38)
End
29807282/29795961 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIF22
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-25-5p ; hsa-mir-149-5p ; hsa-mir-23a-3p
Nearest miRNA
hsa-mir-1225/Upstream/196696; hsa-mir-11401/Downstream/707958;
Nearest TSS
ENST00000527434/Upstream/4990; ENST00000563666/Downstream/925;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4964, chr16-CpG: 267/Downstream/8965
Upstream sequence
TTGCAGAACCCACATAATTCCCCATCAAGAGAAGATCATCATTAACAGTTTGCAGGGGTGGGTGGGTCTGTGAGTATACATACGTCTCAATACATATTAG
Downstream sequence
AAACCCCAGTTAAGAAATGGAGGTACAggctgggcagggtggctcacacctataatcctagcactttgggaggccaaggcaggcagatcacttgaggtca
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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