Basic Information
VIS ID
TVIS30000149
Fusion event
HIV-NCAPH integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
97010414/96344676 (Hg38)
End
97010414/96344676 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NCAPH
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-4266 ; hsa-mir-6834-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5584-5p ; hsa-mir-6888-5p ; hsa-mir-3157-5p ; hsa-mir-3911 ; hsa-mir-4323 ; hsa-mir-451b ; hsa-mir-4690-3p ; hsa-mir-4696 ; hsa-mir-4797-5p ; hsa-mir-5685 ; hsa-mir-574-5p ; hsa-mir-759 ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/7532222; hsa-mir-10b/Downstream/453602;
Nearest TSS
ENST00000437798/Upstream/8858; ENST00000435349/Downstream/19804;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8516, chr2-CpG: 59/Downstream/155795
Upstream sequence
ttaactcatttaatcctcacaacattcttgtatcattttaggaagaggtaactgaggcacaatgacttgcctgaaacgacacatctagtaagtgagctag
Downstream sequence
aagttgaagctaagtggtctaactccagaatcctagctttaaatcatctatCTAGCAAATCCTAAGGAATCGGCTTAAACAAATGGTACTGGAGGCCTCA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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