Basic Information
VIS ID
TVIS30000150
Fusion event
HIV-XPO6 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
28169360/28158039 (Hg38)
End
28169360/28158039 (Hg38)
Orient
+
Location type
Intronic
Target gene
XPO6
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-122-5p ; hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-185-5p ; hsa-mir-222-3p ; hsa-mir-181b-5p ; hsa-mir-16-5p ; hsa-mir-4260 ; hsa-mir-1227-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-6825-5p ; hsa-mir-3180 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-3188 ; hsa-mir-1273e ; hsa-mir-7847-3p ; hsa-mir-885-3p ; hsa-mir-31-5p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-6820-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-576-3p
Nearest miRNA
hsa-mir-1225/Upstream/2132729; hsa-mir-11401/Downstream/232943;
Nearest TSS
ENST00000527434/Upstream/1707; ENST00000635780/Downstream/7380;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/94064, chr16-CpG: 100/Downstream/53161
Upstream sequence
caggcgtgagggggagagctggaggcagtctggcctcctccttggcgggagaggatagggaatgcagagtcaggtatcatatcacacagtgagcagaagt
Downstream sequence
agaggactaaggcacagacgggcaacagcttggagagaccttaaaaagatacagttaaattaaaagtaagaaacagaatgacagttttactataccactt
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate