Basic Information
VIS ID
TVIS30000151
Fusion event
HIV-SLC9A8 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
48452427/49835890 (Hg38)
End
48452427/49835890 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC9A8
miRNAs that regulate target gene
hsa-mir-192-3p ; hsa-mir-6807-5p ; hsa-mir-4792 ; hsa-mir-4480 ; hsa-mir-6830-5p ; hsa-mir-4999-5p ; hsa-mir-4718 ; hsa-mir-1537-5p ; hsa-mir-3607-3p ; hsa-mir-6787-3p ; hsa-mir-3065-3p ; hsa-mir-3662 ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-596 ; hsa-mir-4293
Nearest miRNA
hsa-mir-103a-2/Upstream/2668832; hsa-mir-1-1/Downstream/27969;
Nearest TSS
ENST00000382410/Upstream/22996; ENST00000490250/Downstream/50481;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/22782, chr20-CpG: 40/Downstream/70175
Upstream sequence
ttttcctgcctcagcctccccagtagctgtaattacaggtgcccgccatcacgcccaactgctttttttgtatttttagtagagacggggtttcactatg
Downstream sequence
ttgaccaggctggtcttgaactcctgacctcagcctcccaaagtgctgggattacaggcatgagccaccatgcccagccaattcacccattttaaatgta
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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