Basic Information
VIS ID
TVIS30000154
Fusion event
HIV-SINHCAF integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
31435459/31282525 (Hg38)
End
31435459/31282525 (Hg38)
Orient
-
Location type
UTR3
Target gene
SINHCAF
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-30d-5p ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-601 ; hsa-mir-325 ; hsa-mir-4318 ; hsa-mir-5692a ; hsa-mir-2052 ; hsa-mir-628-3p ; hsa-mir-561-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-5087 ; hsa-mir-3674 ; hsa-mir-4668-5p ; hsa-mir-4328 ; hsa-mir-223-3p ; hsa-mir-1178-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-583 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-665 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-139-3p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-1247-3p ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-34b-3p ; hsa-mir-495-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/5408446; hsa-let-7i/Downstream/11041175;
Nearest TSS
ENST00000382841/Upstream/180257; ENST00000313737/Downstream/15650;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/29914, chr12-CpG: 257/Downstream/41258
Upstream sequence
cagcctggccaacgtggtgaaaccccgtctctactaaaactaaaaaattagccgggtctggtggcgggcacctataaacccagctacttgggaggctgag
Downstream sequence
gcaggagaatcacttgaacccgggagacggaagttgcagtgagccaagatcacgccactgcactccagcctgggtaacaagagcaaaactccgtctcaaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate