Basic Information
VIS ID
TVIS30000157
Fusion event
HIV-VMP1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
57858853/59781492 (Hg38)
End
57858853/59781492 (Hg38)
Orient
-
Location type
Intronic
Target gene
VMP1
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-25-3p ; hsa-mir-4776-3p ; hsa-mir-744-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-7159-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4694-5p ; hsa-mir-5186 ; hsa-mir-7978 ; hsa-mir-181a-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-1324 ; hsa-mir-4709-5p ; hsa-mir-4272 ; hsa-mir-6856-3p ; hsa-mir-513b-3p ; hsa-mir-505-3p ; hsa-mir-421 ; hsa-mir-3161 ; hsa-mir-622 ; hsa-mir-4761-5p ; hsa-mir-624-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-138-2-3p ; hsa-mir-4282 ; hsa-mir-4698 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-555 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-5680 ; hsa-mir-4506 ; hsa-mir-150-3p
Nearest miRNA
hsa-mir-10226/Upstream/415338; hsa-mir-1250/Downstream/59774;
Nearest TSS
ENST00000595228/Upstream/7738; ENST00000588617/Downstream/56136;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/73745, chr17-CpG: 73/Downstream/111189
Upstream sequence
TTTGCATACATAACTTTTTATAAAAATTAGAATCATACCATAAATTTTAGTCACAAGTTCCTTTTTCACAGTATCATAGACATGTGATACCAATGttatt
Downstream sequence
ataaaattattttttattaCGAAGTGATACATCTCATTGTAGAAAATTGGTGAGTGCCCTTTAGTCTTTTCTCTATAAATATTTATATACCTAAGAGTGA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate