Basic Information
VIS ID
TVIS30000161
Fusion event
HIV-SMG1P2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
29580036/29568715 (Hg38)
End
29580036/29568715 (Hg38)
Orient
+
Location type
Inergenic
Target gene
SMG1P2
Nearest miRNA
hsa-mir-1225/Upstream/610054; hsa-mir-11401/Downstream/30464;
Nearest TSS
ENST00000527434/Upstream/62716; ENST00000436527/Downstream/94264;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/84738, chr16-CpG: 103/Downstream/25928
Nearby gene
SMG1P2(-2496) ;
Upstream sequence
AACACTGAGATTTTTTTCCCAAAAAAATTTGTGTTTTCAGAAATATAGCAAAAAAACTGGAATAGAGCCACTGTCTCAGAAATACCTGAAAACTCCCTAG
Downstream sequence
CTGCCAAATTATTTTAATACAAATTGATCAAAGCATCCCCAACCAGAACTCAGGTTGTAAGCATTCTGAACCTAAAAGCACAAAATGGTTTAGCATTTAT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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