Basic Information
VIS ID
TVIS30000166
Fusion event
HIV-ZNF84 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133619221/133042635 (Hg38)
End
133619221/133042635 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ZNF84
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-mir-526b-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-1264 ; hsa-mir-4428 ; hsa-mir-4803 ; hsa-mir-744-3p ; hsa-mir-4433b-5p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-4474-5p ; hsa-mir-4684-3p ; hsa-mir-4433a-5p ; hsa-mir-6760-3p ; hsa-mir-1278 ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-4436b-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-676-5p ; hsa-mir-6513-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-3653-5p
Nearest miRNA
hsa-let-7i/Upstream/460574;
Nearest TSS
ENST00000382841/Upstream/1350; ENST00000543124/Downstream/4986;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/4696, chr12-CpG: 97/Downstream/37483
Upstream sequence
gaaaaaagcgtaggctttatagggtttggttctatctggtttcaggcatccaccggagtcttggaacatctcctttgtggataggtgggggctactgTGG
Downstream sequence
TGGGTAATGTTCTCTAGAGAAACGCTAATAAACGCATGAACCTTACGGCATTTTTCATAGCGTTCTTCAGAGTATGTCCCAAGGGTAGAATGCCAGAGCA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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