Basic Information
VIS ID
TVIS30000171
Fusion event
HIV-HNRNPM integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
8517689/8452805 (Hg38)
End
8517689/8452805 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
HNRNPM
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-let-7f-1-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-191-5p ; hsa-mir-15b-5p ; hsa-mir-183-5p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-29a-3p
Nearest miRNA
hsa-mir-1227/Upstream/63425; hsa-let-7e/Downstream/1585549;
Nearest TSS
ENST00000633603/Upstream/7811; ENST00000593293/Downstream/9164;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6924, chr19-CpG: 60/Downstream/32850
Upstream sequence
GAAGCTGCTTTCCTTGGTTTTACCTTGTGTTGATTTGGGTGTGGCTCACACCAGTGATACCTCTGCTGGGATACCACTTGGCACTCTTGTGTTTGGGGAC
Downstream sequence
TACACAAAGTTGCTGACTTTAAAATTTTTCCAAGTAAATACGTTACTAtttttgagacagggtcttgctttgtcaaccaggctggagtgcagtggtgcaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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