VISDB - VIS Detail

Basic Information

VIS ID

TVIS30000173

Fusion event

HIV-BCAT1 integration

Validated

Yes

Detection method

dd-PCR+WGA

Data source

download(RID)

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Normal

Reported year

2019

PubMed ID

30688658

Virus Sequence

Virus name

HIV

Reference genome

K03455.1

Host Sequence

Chromosome

chr12

Cytoband

p12.1

Reference genome

GRCh37/hg19

Start

24978300/24825366 (Hg38)

End

24978300/24825366 (Hg38)

Orient

Location type

Intronic

Target gene

BCAT1

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-21-5p ; hsa-mir-769-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-3692-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-593-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-7113-5p ; hsa-mir-140-3p ; hsa-mir-4328 ; hsa-mir-211-3p ; hsa-mir-4733-3p ; hsa-mir-6753-5p ; hsa-mir-106a-3p ; hsa-mir-137 ; hsa-mir-3152-3p ; hsa-mir-5589-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-548j-3p ; hsa-mir-548x-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4778-3p ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/612871; hsa-let-7i/Downstream/1048654;

Nearest TSS

ENST00000382841/Upstream/120801; ENST00000545410/Downstream/4962;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/262006, chr12-CpG: 70/Downstream/77299

Upstream sequence

ctttgatatactaatttttttcttttggatatatacccggtggtagaattgctggatcacacggaagttctagttctacttttatttttggaggaccctc

Downstream sequence

catactgttctccatagtggctgtactatttatatttcaaccaacaatatatgatggttccctttctccacatcctcccagcatctgttattgcctgttt

Reference

Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.