Basic Information
VIS ID
TVIS30000174
Fusion event
HIV-PUM1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
p35.2
Reference genome
GRCh37/hg19
Start
31485896/31013049 (Hg38)
End
31485896/31013049 (Hg38)
Orient
+
Location type
Intronic
Target gene
PUM1
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-151a-3p ; hsa-mir-181a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-296-3p ; hsa-mir-324-3p ; hsa-mir-324-5p ; hsa-mir-186-5p ; hsa-mir-99a-5p ; hsa-mir-568 ; hsa-mir-508-3p ; hsa-mir-219a-5p ; hsa-mir-4445-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-142-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-340-5p ; hsa-mir-6809-5p ; hsa-mir-7112-5p ; hsa-mir-4708-3p ; hsa-mir-651-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p ; hsa-mir-335-3p ; hsa-mir-4528 ; hsa-mir-4283 ; hsa-mir-760 ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-3149 ; hsa-mir-5004-3p ; hsa-mir-3618 ; hsa-mir-4696 ; hsa-mir-571 ; hsa-mir-451b ; hsa-mir-4704-5p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-12136/Upstream/273817; hsa-mir-101-1/Downstream/745611;
Nearest TSS
ENST00000473358/Upstream/17945; ENST00000479629/Downstream/48867;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/103930, chr1-CpG: 60/Downstream/52516
Upstream sequence
AAAATGACCTATTGTGTACAATGAAAGAGATAACACATGTAATGACATAATACAATGCTGAAACAGTAAACAAAAAATCAGCTACTATCCTTCTTTAAAA
Downstream sequence
GAGCAAAGTAGCAGCCAATAGACATCACAATACTAATGATTTGTCAATGAAATGCTCCTATGTCAAACTATCAGACACAGTGATCATGGCATCACCTAGG
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate