Basic Information
VIS ID
TVIS30000179
Fusion event
HIV-C5 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr9
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
123723275/120960997 (Hg38)
End
123723275/120960997 (Hg38)
Orient
+
Location type
Intronic
Target gene
C5
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-10a-5p
Nearest miRNA
hsa-let-7a-1/Upstream/715947; hsa-mir-12126/Downstream/1159085;
Nearest TSS
ENST00000422679/Upstream/31824; ENST00000468952/Downstream/1710;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/31600, chr9-CpG: 89/Downstream/113427
Upstream sequence
AAGGACCCAAAATGATAATGTGACTGATTTATAGCTATAAAATGGCACAATAAGTACCTAGAAAATGTGTAGATATTGAGGATTTTGAAAAAACCAAAAC
Downstream sequence
TAACTGAGACCCTCATGGAGCCAGCTGTTGATTATTGGTGAGTTCTGGATCTTTTCCTTGGCCAAGAAGGCTTTCTTCAATTTAGGAAAGACTAAATGGA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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