Basic Information
VIS ID
TVIS30000192
Fusion event
HIV-SLF2 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102723858/100964101 (Hg38)
End
102723858/100964101 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLF2
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-107/Upstream/2039533; hsa-mir-1307/Downstream/10884;
Nearest TSS
ENST00000439456/Upstream/20447; ENST00000609801/Downstream/3587;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/50699, chr10-CpG: 43/Downstream/5441
Upstream sequence
TCTTCAGACTCCAGGTCATAGTCCAGTCAGTATTTGCATTTGGGTTCTCATGAAAACTTTGTGACTCTCTTTTAGCACAAGTAGCCCATGGTTTTTCTTC
Downstream sequence
CAAATCAAGTATTTTACTTCTCCCTTGAGTCCCCATGCTTTGTCTCCCTCCTGCTGCTATTGCCCGGTGAATGGGATGGTAGAGAGGGAGAAATGTTCAT
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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