Basic Information
VIS ID
TVIS30000217
Fusion event
HIV-RRP1B integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
45092460/43672579 (Hg38)
End
45092460/43672579 (Hg38)
Orient
-
Location type
Intronic
Target gene
RRP1B
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-34a-5p ; hsa-mir-98-5p ; hsa-mir-1296-5p ; hsa-mir-940 ; hsa-mir-455-3p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-196b-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-125a-5p ; hsa-mir-10a-5p ; hsa-mir-548m ; hsa-mir-302a-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-452-3p ; hsa-mir-150-5p ; hsa-mir-141-5p ; hsa-mir-891b ; hsa-mir-4772-3p
Nearest miRNA
hsa-let-7c/Upstream/62590; hsa-mir-6815/Downstream/1805687;
Nearest TSS
ENST00000624081/Upstream/13031; ENST00000470886/Downstream/13553;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/12639, chr21-CpG: 21/Downstream/21501
Upstream sequence
AGCTGTGATAAACTTAGTCATTGACTTGGTGAGAGGGCACAGTGTCTTGGGGAGAATCAATTTGACATCTCAAAGATTTCAGAAAATGCTTTTAGAAATA
Downstream sequence
ACAATCCTCCAGAATCTTCAAATTCTGAGTTACTTTAACACTTGGAGCCTGGAGAGCCAGATGCAGGGTCCACGGTGACCTCTGGATGCCAGGTTCGTCT
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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