Basic Information
VIS ID
TVIS30000220
Fusion event
HIV-WDR6 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
49052483/49015050 (Hg38)
End
49052483/49015050 (Hg38)
Orient
+
Location type
Exonic
Target gene
WDR6
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-760 ; hsa-mir-425-5p ; hsa-mir-615-3p ; hsa-mir-222-3p ; hsa-mir-107 ; hsa-mir-92a-3p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-12127/Upstream/370770; hsa-let-7g/Downstream/5098;
Nearest TSS
ENST00000440867/Upstream/811; ENST00000480392/Downstream/1233;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/7257, chr3-CpG: 114/Downstream/2731
Upstream sequence
TCGTGCTTGCTGTGGAGATGCTACAGCTAGAAGAGGCTGTGGGAGAGGCTGGGCTGGTACCCCAGCTGCGTGTGCTAGAGGAATACTCTGTCCCCTGTGC
Downstream sequence
ACATGCTGCCCATGTGACAGGCCTCAAGATCCTAAGCCCAAGCATCATGGTCTCAGCCTCCATTGATCAACGGCTGACCTTCTGGCGTCTGGGGCATGGT
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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