Basic Information
VIS ID
TVIS30000253
Fusion event
HIV-ZNF146 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36718779/36227877 (Hg38)
End
36718779/36227877 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF146
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-149-5p ; hsa-mir-30c-5p ; hsa-mir-3657 ; hsa-mir-1278 ; hsa-mir-3915 ; hsa-mir-4496 ; hsa-mir-4682 ; hsa-mir-548at-5p ; hsa-mir-2053 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-3928-3p ; hsa-mir-4760-3p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p ; hsa-mir-561-3p
Nearest miRNA
hsa-mir-10395/Upstream/882250; hsa-let-7e/Downstream/3181746;
Nearest TSS
ENST00000633603/Upstream/12744; ENST00000587285/Downstream/582;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/12517, chr19-CpG: 67/Downstream/17242
Upstream sequence
cctgcactcaaaacgattcacccacttccggcctcccgaagtgttgggattataggtgtgagccactgcacctggGCCAGGACATCTCTAATATGAAATA
Downstream sequence
GGACACggcacggtggcttacatctgtaatcccagcactttgggaggctgaggtgggtggatcacctaaggtcaggagttcgagaccagcctggccaaca
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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