Basic Information
VIS ID
TVIS30000263
Fusion event
HIV-VPS45 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150085560/150113445 (Hg38)
End
150085560/150113445 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
VPS45
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-186-3p ; hsa-mir-6782-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/1725082; hsa-mir-1182/Downstream/378900;
Nearest TSS
ENST00000473358/Upstream/4270; ENST00000492304/Downstream/35738;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/45687, chr1-CpG: 190/Downstream/36060
Upstream sequence
TTACACACAGTTATTTCATtatgtacggaaaagtatataaatgataaacagctcagtaaaacattgcaaagtgaatatatctatgagatgacctctgagt
Downstream sequence
gtaatgatcaagaaatagcacattgccagcacccccagcagcctttcttattcctcatgctccctccttgtcacaaatccgtgcaaagtattcattatta
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
Curate