Basic Information
VIS ID
TVIS30000273
Fusion event
HIV-BRAP integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
112096234/111658430 (Hg38)
End
112096234/111658430 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
BRAP
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-1296-5p ; hsa-mir-5583-3p ; hsa-mir-664b-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-561-5p ; hsa-mir-3115 ; hsa-mir-4477a ; hsa-mir-6853-3p ; hsa-mir-203a-5p ; hsa-mir-503-3p ; hsa-mir-4761-5p ; hsa-mir-656-3p ; hsa-mir-140-5p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-4474-3p ; hsa-mir-640 ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4318
Nearest miRNA
hsa-let-7i/Upstream/354221; hsa-mir-1178/Downstream/141404;
Nearest TSS
ENST00000382841/Upstream/58754; ENST00000552965/Downstream/14881;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/58676, chr12-CpG: 82/Downstream/27012
Upstream sequence
gctcttgttgcccaagctggagtgcaatgacccgatctcggctcactgcaacctctgcttcccaggttcaagcgattctctgcttcccgggttcaagcga
Downstream sequence
ttctcctgcctcagcctcccgaggagctgggattacaggtgtgtgccaccatgcccagctaattttttgcatttttagtagaaacagggtttcacgttag
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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