Basic Information
VIS ID
TVIS30000288
Fusion event
HIV-CLIC6 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr21
Cytoband
q22.12
Reference genome
GRCh37/hg19
Start
36057508/34685209 (Hg38)
End
36057508/34685209 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLIC6
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-3157-5p ; hsa-mir-5702 ; hsa-mir-4691-3p ; hsa-mir-1288-5p ; hsa-mir-383-5p ; hsa-mir-3925-5p
Nearest miRNA
hsa-let-7c/Upstream/1134481; hsa-mir-3197/Downstream/1035506;
Nearest TSS
ENST00000624081/Upstream/15820; ENST00000419921/Downstream/51972;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/14284, chr21-CpG: 91/Downstream/106638
Upstream sequence
AGCTTTGGTGGGGTGGCAGGGTGGGGGGTGGTGTGTAGGATGCTGCAGTCCAGTAGGAAGAAGCTGATATGCACTCCAGCAATCCCCCAAGCGGTGACCC
Downstream sequence
TGGTCCTCCTCTAGCCACCTGGGGACATGGGGATGATGAATCAAAGCAGAGATGAACAGAGGACACTGTTTTATTCCCTGGCTGGAACACACAGTGATAT
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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