Basic Information
VIS ID
TVIS30000292
Fusion event
HIV-TRERF1 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
42403397/42435659 (Hg38)
End
42403397/42435659 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TRERF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30b-5p ; hsa-mir-101-3p ; hsa-mir-324-5p ; hsa-mir-342-3p ; hsa-mir-377-3p ; hsa-mir-3120-3p ; hsa-mir-603 ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/702049; hsa-mir-10524/Downstream/998883;
Nearest TSS
ENST00000381078/Upstream/217794; ENST00000372903/Downstream/15602;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/175909, chr6-CpG: 18/Downstream/16113
Upstream sequence
ccgcccaaaaagaatctaagatgaacttaaagatttatgtacaaggatatttatcaaagtattatttataatagttaaaaaatgataaataaggtaaatt
Downstream sequence
cctaataatagggactagttaaataagttatggAggccgggcgcagtggctcacacctgtaatcccagcactttgggaagctgaggcgggcagatcacga
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
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