Basic Information
VIS ID
TVIS30000293
Fusion event
HIV-FOXO3 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
108938811/108617608 (Hg38)
End
108938811/108617608 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
FOXO3
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-182-5p ; hsa-mir-197-3p ; hsa-mir-155-5p ; hsa-mir-96-5p ; hsa-mir-23a-3p ; hsa-mir-9-5p ; hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-26a-5p ; hsa-let-7c-5p ; hsa-mir-126-3p ; hsa-mir-29a-3p ; hsa-mir-21-5p ; hsa-mir-590-5p ; hsa-mir-548c-3p ; hsa-mir-126-5p ; hsa-mir-340-5p ; hsa-mir-621 ; hsa-mir-4714-3p ; hsa-mir-4795-5p ; hsa-mir-217 ; hsa-mir-548av-3p ; hsa-mir-671-5p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-4786-3p ; hsa-mir-6079 ; hsa-mir-223-3p ; hsa-mir-218-5p ; hsa-mir-4795-3p ; hsa-mir-6069 ; hsa-mir-665 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-1179 ; hsa-mir-6828-5p ; hsa-mir-1228-3p ; hsa-mir-6882-5p ; hsa-mir-4328 ; hsa-mir-4275 ; hsa-mir-100-3p ; hsa-mir-3927-5p ; hsa-mir-6832-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-5089-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-592 ; hsa-mir-31-5p ; hsa-mir-93-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-10398/Upstream/1833388; hsa-mir-1202/Downstream/10451439;
Nearest TSS
ENST00000381078/Upstream/56742; ENST00000540898/Downstream/38738;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/55407, chr6-CpG: 18/Downstream/45953
Nearest cancer related gene
FOXO3(TSG, No orient, 0)
Upstream sequence
TGCCCTACATATAACAGCTACATACAAAAAAGTTATAAAATTGTCCTTGGTTTTACAGTGATCAATTAAAAACATGAAAATTCTCCAGTTGAACAAGGTA
Downstream sequence
TGCAAGGATTTTTATGGGTTTTTTGTTTGTTTGTTTGTTGTTGTTAAAACAGAGCAAAATAACTTACTGGAATATGAAGAGCAGGATGAGCATGCCACTA
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
Curate