Basic Information
VIS ID
TVIS30000311
Fusion event
HIV-AMBRA1 integration
Validated
No
Detection method
NG-SGS
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30024859
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46502736/46481186 (Hg38)
End
46502736/46481186 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMBRA1
miRNAs that regulate target gene
hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-1231 ; hsa-mir-1299 ; hsa-mir-1343-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-24-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-3928-5p ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4533 ; hsa-mir-485-5p ; hsa-mir-555 ; hsa-mir-571 ; hsa-mir-6128 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6758-5p ; hsa-mir-6776-5p ; hsa-mir-6783-3p ; hsa-mir-6796-3p ; hsa-mir-6806-3p ; hsa-mir-6851-5p ; hsa-mir-6856-5p ; hsa-mir-6861-5p ; hsa-mir-6881-5p ; hsa-mir-6884-5p ; hsa-mir-759 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-129-2/Upstream/29297; hsa-let-7a-2/Downstream/271939;
Nearest TSS
ENST00000527297/Upstream/63191; ENST00000579280/Downstream/12707;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/88049, chr11-CpG: 45/Downstream/112461
Upstream sequence
TGAATGCTGTTCAGATTCCATCTCAAAAACAAATGAGGATGGAGACCAGAGGCCTGCCGTCCCCAGACTGATAAGAGCAGCACGGTGCAATTACACCCAA
Downstream sequence
ACAGCTCTGTTTTGGAATGTAATCACCGCCCCAGCCTTCTTCCCAAAGGGATGGCAACAGTGTAATTACCACTACACAATTCATTGTTTGGGAATATAAT
Reference
Sharaf, R., et al.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. J Clin Invest,2018,128(9): 4074-4085.
Curate